Arf6^tm1Yaka
Targeted Allele Detail

Summary

• Symbol: Arf6^tm1Yaka
• Name: ADP-ribosylation factor 6; targeted mutation 1, Yasunori Kanaho
• MGI ID: MGI:3662650
• Synonyms: Arf6^-
• Gene: Arf6 Location: Chr12:69418924-69420557 bp, + strand Genetic Position: Chr12, 28.81 cM
• Alliance: Arf6^tm1Yaka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111404
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector was designed to replace a fragment encompassing the ATG with a neomycin resistance cassette. Western blot failed to detect protein in mutant MEFs. (J:111404)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arf6 Mutation: 10 strains or lines available

References

• Original: J:111404 Suzuki T, et al., Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol. 2006 Aug;26(16):6149-56
• All: 4 reference(s)