Hsh2d^tm1Viss
Targeted Allele Detail

Summary

• Symbol: Hsh2d^tm1Viss
• Name: hematopoietic SH2 domain containing; targeted mutation 1, Virginia Smith Shapiro
• MGI ID: MGI:3662663
• Synonyms: ALX KO
• Gene: Hsh2d Location: Chr8:72943512-72954802 bp, + strand Genetic Position: Chr8, 34.87 cM
• Alliance: Hsh2d^tm1Viss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111408
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2 and 3. These exons encoded the ATG and the SH2 domain FLVR motif. Western blot failed to detect protein in mutants. (J:111408)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsh2d Mutation: 58 strains or lines available

References

• Original: J:111408 Perchonock CE, et al., Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX. Mol Cell Biol. 2006 Aug;26(16):6005-15
• All: 2 reference(s)