Tg(Igh-6-Cd86)1Akab
Transgene Detail

Summary

• Symbol: Tg(Igh-6-Cd86)1Akab
• Name: transgene insertion 1, Abul K Abbas
• MGI ID: MGI:3662674
• Synonyms: T.B7-2
• Transgene: Tg(Igh-6-Cd86)1Akab Location: unknown
• Alliance: Tg(Igh-6-Cd86)1Akab page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-6-Cd86)1Akab expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd86 (MGI:101773)

• Mutation details: The transgene was composed of the cDNA of the mouse Cd86 coding region under the control of the Igh-6 promoter and enhancer elements. A mutated nonexprressible segment of the human growth hormone gene was included to enhance transgene expression. (J:44271)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:44271 Van Parijs L, et al., Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. J Immunol. 1997 Dec 1;159(11):5336-44
• All: 1 reference(s)