Del(7Gm7290-Th)1Lef
Targeted Allele Detail

Summary

• Symbol: Del(7Gm7290-Th)1Lef
• Name: deletion, Chr 7, Louis Lefebvre 1
• MGI ID: MGI:3662901
• Synonyms: Del1Lef, Del^7AI, Del(7Ascl2-Ins2)1Lef
• Gene: Del(7Gm7290-Th)1Lef Location: Chr7:142236009-142516236 bp Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153719
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Gm7290-Th)1Lef involves 3 genes/genome features (Gm7290, Gm6471, Th) View all
• Mutation details: Cre mediated targeted meiotic recombination (TAMERE) in mice carrying Ins2^tm1.1Nagy and Ascl2^tm2.1Nagy removed the 280 kb genomic fragment between the loxP sites, which includes the Th gene. (J:153719)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(7Gm7290-Th)1Lef Mutation: 1 strain or line available

References

• Original: J:153719 Lefebvre L, et al., The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Hum Mol Genet. 2009 Nov 15;18(22):4255-67
• All: 4 reference(s)