Tg(Ins2-Fas*I246N)1Ach
Transgene Detail

Summary

• Symbol: Tg(Ins2-Fas*I246N)1Ach
• Name: transgene insertion 1, Alexander V Chervonsky
• MGI ID: MGI:3662920
• Synonyms: RIP-Fas^cg, RIP-Fas^cg Tg-Hi, RIP-Fas-lpr^cg, Tg(Ins2-Tnfrsf6^lpr-cg)
• Transgene: Tg(Ins2-Fas*I246N)1Ach Location: unknown
• Alliance: Tg(Ins2-Fas*I246N)1Ach page

Transgene origin

• Strain of Origin: NOD/ShiLt

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Fas*I246N)1Ach expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Fas (246097)

  Fas	(MGI:95484)

• Tg(Ins2-Fas*I246N)1Ach expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: Fas cDNA with a single nucleotide change leading to a I246N change in protein sequence, which codes for Fas^cg was subcloned into the rat insulin 2 promoter and injected into NOD/Lt oocytes to produce transgenic mice. (J:81416)
• Inheritance: Dominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:81416 Savinov AY, et al., Contribution of Fas to diabetes development. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):628-32
• All: 1 reference(s)