Timp4^tm1Vuo
Targeted Allele Detail

Summary

• Symbol: Timp4^tm1Vuo
• Name: tissue inhibitor of metalloproteinase 4; targeted mutation 1, Eero Vuorio
• MGI ID: MGI:3663251
• Gene: Timp4 Location: Chr6:115221405-115229166 bp, - strand Genetic Position: Chr6, 53.29 cM
• Alliance: Timp4^tm1Vuo page

Cardiac rupture, decreased collagen synthesis, and disruption of collagen network in Timp4^tm1Vuo/Timp4^tm1Vuo hearts after myocardial infarction

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112210
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1 through 3 were replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on heart extracts. (J:165901)

Generation of the Timp4^tm1Vuo allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Timp4 Mutation: 14 strains or lines available

References

• Original: J:112210 English JL, et al., Individual Timp deficiencies differentially impact pro-MMP-2 activation. J Biol Chem. 2006 Apr 14;281(15):10337-46
• All: 4 reference(s)