Clic5^jbg
Spontaneous Allele Detail

Summary

• Symbol: Clic5^jbg
• Name: chloride intracellular channel 5; jitterbug
• MGI ID: MGI:3663254
• Gene: Clic5 Location: Chr17:44445671-44591059 bp, + strand Genetic Position: Chr17, 20.53 cM, cytoband C
• Alliance: Clic5^jbg page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 97 base pair deletion, including the 3'-most 87 base pairs of exon 5 and 10 base pairs of the flanking intron sequence including the exon/intron splice donor recognition sequence, results in a frame shift and premature stop codon in both Clic5A and Clic5B transcripts, effectively resulting in a null mutation of both transcripts. (J:112741)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Clic5 Mutation: 20 strains or lines available

References

• Original: J:112741 Gagnon LH, et al., The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. J Neurosci. 2006 Oct 4;26(40):10188-98
• All: 10 reference(s)