Gata6^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Gata6^tm1Eno
• Name: GATA binding protein 6; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3663288
• Gene: Gata6 Location: Chr18:11052510-11085636 bp, + strand Genetic Position: Chr18, 5.63 cM
• Alliance: Gata6^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111824
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin resistance cassette. Exon 2 is the first coding exon, encoding amino acids 1-372, and its deletion resulted in a null allele. (J:111824)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata6 Mutation: 35 strains or lines available

References

• Original: J:111824 Xin M, et al., A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11189-94
• All: 2 reference(s)