Tasp1^tm1.1Jjdh
Targeted Allele Detail

Summary

• Symbol: Tasp1^tm1.1Jjdh
• Name: taspase, threonine aspartase 1; targeted mutation 1.1, James J Hsieh
• MGI ID: MGI:3663289
• Synonyms: Tasp1^-
• Gene: Tasp1 Location: Chr2:139675400-139908725 bp, - strand Genetic Position: Chr2, 69.2 cM
• Alliance: Tasp1^tm1.1Jjdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112159
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 9 and a floxed PGK neo cassette was inserted into intron 9. Successfully targeted ES cells were subsequently transiently transfected with CMV-cre to excise both exon9 9 and the PGKneo. Protein was not detected in mutant MEFs. (J:112159)

Expression

In Mice Carrying this Mutation:	24 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tasp1 Mutation: 38 strains or lines available

References

• Original: J:112159 Takeda S, et al., Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression. Genes Dev. 2006 Sep 1;20(17):2397-409
• All: 6 reference(s)