Rr383^tm1Caob
Targeted Allele Detail

Summary

• Symbol: Rr383^tm1Caob
• Name: regulatory region 383; targeted mutation 1, Charles A O'Brien
• MGI ID: MGI:3663313
• Synonyms: Cigs1^tm1Caob, DCR^-
• Gene: Rr383 Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Rr383^tm1Caob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112132
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced a 2,372 bp sequence containing a Tnfsf11 enhancer. The neo cassette was removed through subsequent cre-mediated recombination. (J:112132)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr383 Mutation: 0 strains or lines available

References

• Original: J:112132 Fu Q, et al., Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol. 2006 Sep;26(17):6453-68
• All: 4 reference(s)