Blm^tm4Ches
Targeted Allele Detail

Summary

• Symbol: Blm^tm4Ches
• Name: Bloom syndrome, RecQ like helicase; targeted mutation 4, Nicholas Chester
• MGI ID: MGI:3663359
• Synonyms: Blm^flox
• Gene: Blm Location: Chr7:80104839-80184896 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Blm^tm4Ches page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112115
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neomycin resistance gene was inserted into intron 8 and an additional loxP site was placed in intron 7, 75 bp from the start of exon 8. Transient cre expression removed the PGK-neo sequence from correctly targeted ES cells, leaving loxP sites flanking exon 8. (J:112115)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Blm Mutation: 88 strains or lines available

References

• Original: J:112115 Chester N, et al., Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol. 2006 Sep;26(17):6713-26
• All: 9 reference(s)