Igfbp3^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Igfbp3^tm1Jep
• Name: insulin-like growth factor binding protein 3; targeted mutation 1, John E Pintar
• MGI ID: MGI:3663361
• Synonyms: BP3KO
• Gene: Igfbp3 Location: Chr11:7156086-7163923 bp, - strand Genetic Position: Chr11, 4.75 cM
• Alliance: Igfbp3^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112029
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1, including the translation start site and signal peptide, was replaced by a neomycin resistance cassette. Western blot failed to detect protein in mutants. (J:112029)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igfbp3 Mutation: 21 strains or lines available

References

• Original: J:112029 Ning Y, et al., Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Mol Endocrinol. 2006 Sep;20(9):2173-86
• All: 14 reference(s)