Ptpn1^tm2Bbk
Targeted Allele Detail

Summary

• Symbol: Ptpn1^tm2Bbk
• Name: protein tyrosine phosphatase, non-receptor type 1; targeted mutation 2, Barbara B Kahn
• MGI ID: MGI:3663370
• Synonyms: PTP-1B^fl, Ptpn^flox
• Gene: Ptpn1 Location: Chr2:167773977-167821305 bp, + strand Genetic Position: Chr2, 87.99 cM, cytoband H3
• Alliance: Ptpn1^tm2Bbk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111969
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exons 6-8 of the locus. This sequence encompasses the active site and surrounding parts of the catalytic domain. A floxed neo was removed via cre mediated excision. (J:111969)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn1 Mutation: 36 strains or lines available

References

• Original: J:111969 Bence KK, et al., Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006 Aug;12(8):917-24
• All: 51 reference(s)