Gpr12^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Gpr12^tm1Dgen
• Name: G-protein coupled receptor 12; targeted mutation 1, Deltagen
• MGI ID: MGI:3663376
• Synonyms: Gpr12^-
• Gene: Gpr12 Location: Chr5:146519208-146522049 bp, - strand Genetic Position: Chr5, 85.23 cM
• Alliance: Gpr12^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111942
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-pA-PGK-neo-pA cassette replaced a sequence of exon 2 corresponding to nucleotides 155-507. LacZ expression was visualized in mutant brain sections. (J:111942)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr12 Mutation: 17 strains or lines available

References

• Original: J:111942 Bjursell M, et al., G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. Biochem Biophys Res Commun. 2006 Sep 22;348(2):359-66
• All: 3 reference(s)