Ncam2^tm1Mom
Targeted Allele Detail

Summary

• Symbol: Ncam2^tm1Mom
• Name: neural cell adhesion molecule 2; targeted mutation 1, Peter Mombaerts
• MGI ID: MGI:3663377
• Synonyms: OCAM-exon4-inversion
• Gene: Ncam2 Location: Chr16:80997585-81423716 bp, + strand Genetic Position: Chr16, 45.89 cM, cytoband C1-3
• Alliance: Ncam2^tm1Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111928
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Inversion
• Ncam2^tm1Mom involves 1 genes/genome features (Ncam2) View all
• Mutation details: A targeting vector was designed to insert loxP sites flanking exon 4 and an frt-flanked neo cassette such that expression of cre recombinase in the germline resulted in the inversion of the sequence. The mutant allele expresses mRNA containing an inversion of exon 4. Western blot failed to detect protein in mutant brains. (J:111928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncam2 Mutation: 87 strains or lines available

References

• Original: J:111928 Walz A, et al., Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAM. Mol Cell Neurosci. 2006 May-Jun;32(1-2):1-14
• All: 2 reference(s)