Scnn1g^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Scnn1g^tm1Bhk
• Name: sodium channel, nonvoltage-gated 1 gamma; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:3663382
• Synonyms: gammaENaC^-
• Gene: Scnn1g Location: Chr7:121333702-121367698 bp, + strand Genetic Position: Chr7, 65.07 cM
• Alliance: Scnn1g^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50528
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the exon with the putative start codon. Northern blot analysis on RNA derived from kidney demonstrated that no detectable protein is expressed from this allele. (J:50528)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scnn1g Mutation: 33 strains or lines available

References

• Original: J:50528 Barker PM, et al., Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism. J Clin Invest. 1998 Oct 15;102(8):1634-40
• All: 2 reference(s)