Jph4^tm1Hta
Targeted Allele Detail

Summary

• Symbol: Jph4^tm1Hta
• Name: junctophilin 4; targeted mutation 1, Hiroshi Takeshima
• MGI ID: MGI:3663386
• Synonyms: JP-4^-
• Gene: Jph4 Location: Chr14:55344283-55354392 bp, - strand Genetic Position: Chr14, 28.07 cM
• Alliance: Jph4^tm1Hta page

Irregular hindlimb reflex in Jph3^tm1Hta/Jph3^tm1Hta Jph4^tm1Hta/Jph4^tm1Hta mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111805
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace all of exon 2 and parts of exon 1 and 3 with a neomycin resistance cassette. Northern blot failed to detect transcript in mutant brain samples. Western blot failed to detect protein in mutant brain samples as well. (J:111805)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jph4 Mutation: 23 strains or lines available

References

• Original: J:111805 Moriguchi S, et al., Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10811-6
• All: 4 reference(s)