Igk-J^tm1.1Cog
Targeted Allele Detail

Summary

• Symbol: Igk-J^tm1.1Cog
• Name: immunoglobulin kappa chain, joining region; targeted mutation 1.1, Michel Cogne
• MGI ID: MGI:3663521
• Synonyms: kappaD
• Gene: Igk-J Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110100
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The Jk cluster was removed by homologous recombination followed by cre mediated excision. Northern blot failed to detect transcript in mutant spleen. (J:110100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk-J Mutation: 11 strains or lines available

References

• Original: J:110100 Sirac C, et al., Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7747-52
• All: 1 reference(s)