Hs6st1^{Gt(betageo)1Tprt}
Gene trapped Allele Detail

Summary

• Symbol: Hs6st1^{Gt(betageo)1Tprt}
• Name: heparan sulfate 6-O-sulfotransferase 1; gene trap 1, Thomas Pratt
• MGI ID: MGI:3663624
• Synonyms: Hs6st^-, Hs6st^LacZ, Hs6st^{LacZ-ires-hPLAP}
• Gene: Hs6st1 Location: Chr1:36107481-36145527 bp, + strand Genetic Position: Chr1, 15.15 cM, cytoband B
• Alliance: Hs6st1^{Gt(betageo)1Tprt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110040
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a splice acceptor, an ORF encoding a CD4 transmembrane domain, a lacZ/neo fusion cassette, and an IRES and PLAP coding region followed by a polyA signal was inserted into intron 1. RT-PCR confired the absence of wild-type transcript in mutants. (J:110040)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hs6st1 Mutation: 27 strains or lines available

References

• Original: J:110040 Pratt T, et al., Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm. J Neurosci. 2006 Jun 28;26(26):6911-23
• All: 9 reference(s)