Ints1^tm1Mnkm
Targeted Allele Detail

Summary

• Symbol: Ints1^tm1Mnkm
• Name: integrator complex subunit 1; targeted mutation 1, Manabu Nakayama
• MGI ID: MGI:3663683
• Synonyms: Ints1^tm1Mknm, KIAA1440^-
• Gene: Ints1 Location: Chr5:139737037-139761429 bp, - strand Genetic Position: Chr5, 78.8 cM, cytoband G1
• Alliance: Ints1^tm1Mnkm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111319
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence of 606 bp was deleted, including exons 24 and 25. Northern blot and RT-PCR of failed to detect intact transcript in mutants. (J:111319)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ints1 Mutation: 70 strains or lines available

References

• Original: J:111319 Nakayama M, et al., A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. FASEB J. 2006 Aug;20(10):1718-20
• All: 2 reference(s)