Kndc1^tm1Mnkm
Targeted Allele Detail

Summary

• Symbol: Kndc1^tm1Mnkm
• Name: kinase non-catalytic C-lobe domain (KIND) containing 1; targeted mutation 1, Manabu Nakayama
• MGI ID: MGI:3663685
• Synonyms: KIAA1768^-
• Gene: Kndc1 Location: Chr7:139474612-139521450 bp, + strand Genetic Position: Chr7, 84.89 cM
• Alliance: Kndc1^tm1Mnkm page

Increased branches and terminals of cerebellar granule cell dendrites in Kndc1^tm1Mnkm/Kndc1^tm1Mnkm cerebella

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111319
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence of 700 bp, including part of exons 4 and 5, was replaced with a neo cassette. Northern blot analysis of RNA purified from adult brains failed to detect intact mRNA transcript in homozygous mutant mice. (J:111319)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kndc1 Mutation: 94 strains or lines available

References

• Original: J:111319 Nakayama M, et al., A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. FASEB J. 2006 Aug;20(10):1718-20
• All: 2 reference(s)