Fyb1^tm1Gak
Targeted Allele Detail

Summary

• Symbol: Fyb1^tm1Gak
• Name: FYN binding protein 1; targeted mutation 1, Gary A Koretzky
• MGI ID: MGI:3663737
• Synonyms: ADAP^-, Fyb^-
• Gene: Fyb1 Location: Chr15:6552334-6692794 bp, + strand Genetic Position: Chr15, 3.19 cM, cytoband A1
• Alliance: Fyb1^tm1Gak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111368
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neomycin resistance cassette. (J:111368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fyb1 Mutation: 42 strains or lines available

References

• Original: J:111368 Peterson EJ, et al., Coupling of the TCR to integrin activation by Slap-130/Fyb. Science. 2001 Sep 21;293(5538):2263-5
• All: 30 reference(s)