Prmt2^tm1Enbl
Targeted Allele Detail

Summary

• Symbol: Prmt2^tm1Enbl
• Name: protein arginine N-methyltransferase 2; targeted mutation 1, Elizabeth G Nabel
• MGI ID: MGI:3663741
• Synonyms: Prmt2^-
• Gene: Prmt2 Location: Chr10:76043060-76073699 bp, - strand Genetic Position: Chr10, 38.74 cM
• Alliance: Prmt2^tm1Enbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111352
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: A point mutation was introduced to create a G119stop codon mutation at exon 4. A neomycin resistance cassette replaced the 3' region of exon 4 and all of exon 5 and part of exon 6. Northern blot failed to detect transcript in mutants. (J:111352)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Prmt2^tm1Enbl/Prmt2^tm1Enbl	involves: 129S2/SvPas

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
abnormal vascular wound healing	√
cellular	√
abnormal cell cycle	√
homeostasis/metabolism	√
abnormal vascular wound healing	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prmt2 Mutation: 42 strains or lines available

References

• Original: J:111352 Yoshimoto T, et al., The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp Cell Res. 2006 Jul 1;312(11):2040-53
• All: 5 reference(s)