Adipoq^tm1Far
Targeted Allele Detail

Summary

• Symbol: Adipoq^tm1Far
• Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Bob Farese
• MGI ID: MGI:3663753
• Synonyms: Adipoq^-, Adipoq^tm1Rvf
• Gene: Adipoq Location: Chr16:22965286-22976718 bp, + strand Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
• Alliance: Adipoq^tm1Far page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111346
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 2 with a neomycin resistance cassette. Protein was not detected by ELISA or immunoblotting, confirming the complete ablation of the locus. (J:111346)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adipoq Mutation: 40 strains or lines available

References

• Original: J:111346 Streeper RS, et al., Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E388-94
• All: 3 reference(s)