Lin9^tm1Orc
Targeted Allele Detail

Summary

• Symbol: Lin9^tm1Orc
• Name: lin-9 DREAM MuvB core complex component; targeted mutation 1, Oscar R Colamonici
• MGI ID: MGI:3663755
• Synonyms: BARA^delta84
• Gene: Lin9 Location: Chr1:180468715-180518252 bp, + strand Genetic Position: Chr1, 84.46 cM
• Alliance: Lin9^tm1Orc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111333
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: In an attempt to produce a knockout by deleting exons 2 and 3, the presence of an alternative ATG in exon 4 resulted in a deletion of the first 84 amino acids of the protein. (J:111333)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lin9 Mutation: 50 strains or lines available

References

• Original: J:111333 Sandoval R, et al., A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes. Exp Cell Res. 2006 Aug 1;312(13):2465-75
• All: 1 reference(s)