Bst1^tm1Thir
Targeted Allele Detail

Summary

• Symbol: Bst1^tm1Thir
• Name: bone marrow stromal cell antigen 1; targeted mutation 1, Toshio Hirano
• MGI ID: MGI:3663800
• Synonyms: BST-1^-
• Gene: Bst1 Location: Chr5:43976235-44000810 bp, + strand Genetic Position: Chr5, 23.84 cM
• Alliance: Bst1^tm1Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111424
• Parent Cell Line: E14.1TG3B1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector was designed to replace sequence encoding part of exon 1, all of exon 2 and part of exon 3 with a neomycin resistnce cassette in opposite transcriptional orientation. RT-PCR confirmed absence of transcript in mutant bone marrow, spleen and thymus. (J:111424)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bst1 Mutation: 26 strains or lines available

References

• Original: J:111424 Itoh M, et al., Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J Immunol. 1998 Oct 15;161(8):3974-83
• All: 12 reference(s)