Metap2^tm1.2Ccr
Targeted Allele Detail

Summary

• Symbol: Metap2^tm1.2Ccr
• Name: methionine aminopeptidase 2; targeted mutation 1.2, Craig M Crews
• MGI ID: MGI:3663890
• Synonyms: MAP2^D
• Gene: Metap2 Location: Chr10:93694351-93732952 bp, - strand Genetic Position: Chr10, 48.69 cM
• Alliance: Metap2^tm1.2Ccr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111701
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two loxP sites were inserted into the 5' UTR and the first intron via homologous recombination. A neomycin resistance gene flanked by two frt sequences was also introduced into the intron. Floxed mice with the neomycin resistance gene were crossed with Tg(ACTB-cre)2Mrt mice to remove the floxed exon 1. (J:111701)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Metap2 Mutation: 33 strains or lines available

References

• Original: J:111701 Yeh JR, et al., Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10379-84
• All: 1 reference(s)