Kmt2a^tm1(AFF1)Ksy
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1(AFF1)Ksy
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, John H Kersey
• MGI ID: MGI:3663920
• Synonyms: Mll-AF4
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1(AFF1)Ksy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110241
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A vector was designed to fuse the 5' portion of the locus with the 3' portion of human AFF1 and a neomycin resistance cassette. A fusion protein was detected in mutant ES cells by Western blot. (J:110241)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:110241 Chen W, et al., A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. Blood. 2006 Jul 15;108(2):669-77
• All: 1 reference(s)