Gipc1^tm1Mvc
Targeted Allele Detail

Summary

• Symbol: Gipc1^tm1Mvc
• Name: GIPC PDZ domain containing family, member 1; targeted mutation 1, Moses V Chao
• MGI ID: MGI:3663921
• Synonyms: Gipc1^-, synectin-null
• Gene: Gipc1 Location: Chr8:84379306-84391323 bp, + strand Genetic Position: Chr8, 40.22 cM, cytoband C3
• Alliance: Gipc1^tm1Mvc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111724
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 2-4, which encode the entire N-terminal, PDZ and a part of the C-terminal domain, with a neomycin resistance gene. Expression was not detected by Western blot of mutant brain lysates. (J:111724)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gipc1 Mutation: 42 strains or lines available

References

• Original: J:111724 Yano H, et al., BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci. 2006 Aug;9(8):1009-18
• All: 2 reference(s)