Tg(Myh6-Lef1)2Tfo
Transgene Detail

Summary

• Symbol: Tg(Myh6-Lef1)2Tfo
• Name: transgene insertion 2, Thomas Force
• MGI ID: MGI:3664022
• Synonyms: Lef-1delta20
• Transgene: Tg(Myh6-Lef1)2Tfo Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(Myh6-Lef1)2Tfo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Lef1)2Tfo expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lef1 (MGI:96770)

• Mutation details: This transgene consists of the cDNA encoding Lef1 deleted for the first 20 amino acids (that contains the primary beta-catenin binding domain) with an amino-terminal HA tag under the control of the murine alpha-myosin heavy chain promoter. Transgenics show cardiac specific expression of an inhibitory mutant of Lef1. (J:109612)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:109612 Chen X, et al., The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Mol Cell Biol. 2006 Jun;26(12):4462-73
• All: 1 reference(s)