Sh3bp2^tm1Geha
Targeted Allele Detail

Summary

• Symbol: Sh3bp2^tm1Geha
• Name: SH3-domain binding protein 2; targeted mutation 1, Raif S Geha
• MGI ID: MGI:3664088
• Synonyms: 3bp2^-
• Gene: Sh3bp2 Location: Chr5:34683182-34720985 bp, + strand Genetic Position: Chr5, 17.89 cM
• Alliance: Sh3bp2^tm1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110319
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector was designed to replace the 3' half of exon 6 and all of exons 7 through 13 with a neomycin resistance cassette. This sequence includes the proline-rich region and the SH2 domain. Transcript was not detected in mutant mice. (J:110319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3bp2 Mutation: 35 strains or lines available

References

• Original: J:110319 de la Fuente MA, et al., 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol. 2006 Jul;26(14):5214-25
• All: 1 reference(s)