Atp2b2jog
Spontaneous Allele Detail
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Symbol: |
Atp2b2jog |
Name: |
ATPase, Ca++ transporting, plasma membrane 2; joggle |
MGI ID: |
MGI:3664103 |
Gene: |
Atp2b2 Location: Chr6:113720803-114019574 bp, - strand Genetic Position: Chr6, 52.85 cM
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Alliance: |
Atp2b2jog page
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Allele Type: |
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Spontaneous |
Mutation: |
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Transposon insertion
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Mutation details: An intracisternal A particle (IAP) was found to have inserted at the downstream donor splice site of exon 1. Primary transcripts are prematurely terminated and a chimeric mRNA including fused IAP sequence is produced. Expression of full length mRNA is reduced to about 5% of normal. Expression of full length and chimeric mRNA is reduced to about 60% relative to controls.
(J:132712)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6 * DSO | |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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limb grasping
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tremors
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ataxia
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impaired limb coordination
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abnormal posture
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cellular
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abnormal cell death
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growth/size/body
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decreased body weight
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nervous system
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small cerebellum
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:111625 Chen Z, et al., A novel mutant mouse, joggle, with inherited ataxia. Exp Anim. 2006 Jul;55(4):411-4 |
All: |
2 reference(s) |
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