Atp2b2^jog
Spontaneous Allele Detail

Summary

• Symbol: Atp2b2^jog
• Name: ATPase, Ca++ transporting, plasma membrane 2; joggle
• MGI ID: MGI:3664103
• Gene: Atp2b2 Location: Chr6:113720803-114019574 bp, - strand Genetic Position: Chr6, 52.85 cM
• Alliance: Atp2b2^jog page

Mutation origin

• Strain of Origin: DSO

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: An intracisternal A particle (IAP) was found to have inserted at the downstream donor splice site of exon 1. Primary transcripts are prematurely terminated and a chimeric mRNA including fused IAP sequence is produced. Expression of full length mRNA is reduced to about 5% of normal. Expression of full length and chimeric mRNA is reduced to about 60% relative to controls. (J:132712)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atp2b2 Mutation: 66 strains or lines available

References

• Original: J:111625 Chen Z, et al., A novel mutant mouse, joggle, with inherited ataxia. Exp Anim. 2006 Jul;55(4):411-4
• All: 2 reference(s)