Pyy^tm1(cre)Hhzg
Targeted Allele Detail

Summary

• Symbol: Pyy^tm1(cre)Hhzg
• Name: peptide YY; targeted mutation 1, H Herzog
• MGI ID: MGI:3664105
• Synonyms: Pyy^-
• Gene: Pyy Location: Chr11:101997502-101998658 bp, - strand Genetic Position: Chr11, 65.48 cM
• Alliance: Pyy^tm1(cre)Hhzg page

Greater bone mass in Pyy^tm1(cre)Hhzg/Pyy^tm1(cre)Hhzg mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111480
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pyy^tm1(cre)Hhzg expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pyy (MGI:99924)

• Mutation details: A vector was designed to knock out gene function but allow the endogenous promoter to drive expression of cre-recombinase by inducible tetracycline promoter regulation. (J:111480)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pyy (mouse) Summary of all recombinase alleles driven by Pyy. Alliance mouse Pyy gene page

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pyy Mutation: 9 strains or lines available

References

• Original: J:111480 Boey D, et al., Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity. Diabetologia. 2006 Jun;49(6):1360-1370
• All: 8 reference(s)