Tnfrsf11a^del8
Spontaneous Allele Detail

Summary

• Symbol: Tnfrsf11a^del8
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; deletion 8
• MGI ID: MGI:3664109
• Synonyms: Rank^del8
• Gene: Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
• Alliance: Tnfrsf11a^del8 page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: This allele contains an 8 bp deletion in exon 2 encompassing codons 79 and 80, producing a frame shift with a stop codon 3 bp from the deletion. The predicted product is truncated at the proximal end of the second of four extracellular cysteine-rich domains. (J:111512)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11a Mutation: 42 strains or lines available

References

• Original: J:111512 Kapur RP, et al., Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank. J Bone Miner Res. 2004 Oct;19(10):1689-97
• All: 1 reference(s)