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Hspa5tm1.1Alee
Targeted Allele Detail
Summary
Symbol: Hspa5tm1.1Alee
Name: heat shock protein 5; targeted mutation 1.1, Amy S Lee
MGI ID: MGI:3664111
Synonyms: Grp78-
Gene: Hspa5  Location: Chr2:34662102-34666541 bp, + strand  Genetic Position: Chr2, 22.94 cM
Alliance: Hspa5tm1.1Alee page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111416
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA vector was designed to insert a floxed neo into intron 4 and a third loxP site into intron 7. Cre expression in the germline resulted in the excision of exons 5-7. (J:111416)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hspa5 Mutation:  39 strains or lines available
References
Original:  J:111416 Luo S, et al., GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol. 2006 Aug;26(15):5688-97
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory