Hspa5^tm1.1Alee
Targeted Allele Detail

Summary

• Symbol: Hspa5^tm1.1Alee
• Name: heat shock protein 5; targeted mutation 1.1, Amy S Lee
• MGI ID: MGI:3664111
• Synonyms: Grp78^-
• Gene: Hspa5 Location: Chr2:34662102-34666541 bp, + strand Genetic Position: Chr2, 22.94 cM
• Alliance: Hspa5^tm1.1Alee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111416
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A vector was designed to insert a floxed neo into intron 4 and a third loxP site into intron 7. Cre expression in the germline resulted in the excision of exons 5-7. (J:111416)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hspa5 Mutation: 39 strains or lines available

References

• Original: J:111416 Luo S, et al., GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol. 2006 Aug;26(15):5688-97
• All: 15 reference(s)