Map3k7^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Map3k7^tm1Aki
• Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3664193
• Synonyms: Map3k7^flox, TAK1^FL, TAK1^fx
• Gene: Map3k7 Location: Chr4:31964097-32023467 bp, + strand Genetic Position: Chr4, 13.91 cM
• Alliance: Map3k7^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112597
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 2 with loxP sites. This exon encodes part of the kinase domain, including the ATP-binding site. (J:112597)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Map3k7^tm1Aki

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k7 Mutation: 54 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease J: 238318.

References

• Original: J:112597 Sato S, et al., Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005 Nov;6(11):1087-95
• All: 61 reference(s)