Myh6^tm2Jse
Targeted Allele Detail

Summary

• Symbol: Myh6^tm2Jse
• Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 2, Jonathan G Seidman
• MGI ID: MGI:3664197
• Synonyms: R453C, RC
• Gene: Myh6 Location: Chr14:55179378-55204384 bp, - strand Genetic Position: Chr14, 28.01 cM
• Alliance: Myh6^tm2Jse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95600
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeted mutation causes an R453C mutation in the protein product. A detailed description of this allele has not yet been published. (J:95600)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh6 Mutation: 206 strains or lines available

References

• Original: J:95600 Palmer BM, et al., Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium. Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H91-9
• All: 4 reference(s)