Pirb^tm1Stz
Targeted Allele Detail

Summary

• Symbol: Pirb^tm1Stz
• Name: paired Ig-like receptor B; targeted mutation 1, Carla J Shatz
• MGI ID: MGI:3664198
• Synonyms: PirBTM
• Gene: Pirb Location: Chr7:3715504-3723381 bp, - strand Genetic Position: Chr7, 2.14 cM
• Alliance: Pirb^tm1Stz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112843
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination was used to remove exons 10-13. These exons encode the transmembrane domain and part of the intracellular domain. Western blot failed to detect protein in mutants. This allele was generated from Pirb^tm1Stz. (J:112843)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pirb Mutation: 65 strains or lines available

References

• Original: J:112843 Syken J, et al., PirB restricts ocular-dominance plasticity in visual cortex. Science. 2006 Sep 22;313(5794):1795-800
• All: 12 reference(s)