Sumo1^{Gt(RRQ016)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Sumo1^{Gt(RRQ016)Byg}
• Name: small ubiquitin-like modifier 1; gene trap RRQ016, BayGenomics
• MGI ID: MGI:3664241
• Synonyms: Sumo1^Gt, Sumo1^{Gt(pGT1Lxf)9Byg}, Sumo1^{Gt(pGT1Lxf)Byg}
• Gene: Sumo1 Location: Chr1:59678593-59709993 bp, - strand Genetic Position: Chr1, 30.32 cM, cytoband C2-C3
• Alliance: Sumo1^{Gt(RRQ016)Byg} page

Mutation origin

• Mutant Cell Line: RRQ016
• Germline Transmission: Earliest citation of germline transmission: J:112841
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing a betagalactosidase was inserted into the locus, resulting in a hypomorphic allele (J:112841). Gene trap insertion in intron 1 involves a 3kb duplication of host sequence and protein expression is normal (J:141678). (J:112841, J:141678)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRQ016	CG784361 ; (MGI Seq Detail)	5' RACE	Chr1:59709840-59709927 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  137 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sumo1 Mutation: 66 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:112841 Alkuraya FS, et al., SUMO1 haploinsufficiency leads to cleft lip and palate. Science. 2006 Sep 22;313(5794):1751
• All: 7 reference(s)