Actg1^tm1Erv
Targeted Allele Detail

Summary

• Symbol: Actg1^tm1Erv
• Name: actin, gamma, cytoplasmic 1; targeted mutation 1, James M Ervasti
• MGI ID: MGI:3664246
• Synonyms: Actg1⁰, Actg1^flox+neo
• Gene: Actg1 Location: Chr11:120236513-120239321 bp, - strand Genetic Position: Chr11, 84.07 cM, cytoband E2
• Alliance: Actg1^tm1Erv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112808
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neomycin cassette in inverse orientation was inserted in intron 1 and a third loxP site wis placed in intron 3. Exons 2 and 3 are thus flanked by loxP sites. (J:112808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actg1 Mutation: 23 strains or lines available

References

• Original: J:112808 Sonnemann KJ, et al., Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy. Dev Cell. 2006 Sep;11(3):387-97
• All: 3 reference(s)