Tg(Myh6-Agtr1a)4-7Vjd
Transgene Detail

Summary

• Symbol: Tg(Myh6-Agtr1a)4-7Vjd
• Name: transgene insertion 4-7, Victor J Dzau
• MGI ID: MGI:3664306
• Synonyms: alphaMHC-AT1, alphaMHC-AT1 M4/7
• Transgene: Tg(Myh6-Agtr1a)4-7Vjd Location: unknown
• Alliance: Tg(Myh6-Agtr1a)4-7Vjd page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Agtr1a)4-7Vjd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Agtr1a (MGI:87964)

• Mutation details: This transgene consists of the murine alpha-myosin heavy chain promoter driving the expression of mouse Agtr1a (angiotensin II type 1 receptor). Additionally, a tyrosinase minigene was co-injected with the transgene construct to allow visual identification of transgenic offspring coat color. Radioligand binding studies and RT-PCR confirm the specific expression of the transgene in cardiomyocytes. (J:40974)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:40974 Hein L, et al., Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6391-6
• All: 2 reference(s)