Irf4^tm1Rdf
Targeted Allele Detail

Summary

• Symbol: Irf4^tm1Rdf
• Name: interferon regulatory factor 4; targeted mutation 1, Riccardo Dalla-Favera
• MGI ID: MGI:3664434
• Synonyms: Irf4^fl
• Gene: Irf4 Location: Chr13:30933209-30950959 bp, + strand Genetic Position: Chr13, 13.28 cM, cytoband A3.3
• Alliance: Irf4^tm1Rdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112643
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to insert an frt-EGFP-loxP sequence upstream of exon 1 and a loxP-PGK-frt downstream of exon 2 such that cre mediated excision would remove the exons while allowing EGFP expression and, alternatively, FLP-mediated excision would remove both the exons and the EGFP. (J:112643)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf4 Mutation: 28 strains or lines available

References

• Original: J:112643 Klein U, et al., Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol. 2006 Jul;7(7):773-82
• All: 117 reference(s)