Tlr5^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr5^tm1Aki
• Name: toll-like receptor 5; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3664436
• Synonyms: T5KO, Tlr5^-
• Gene: Tlr5 Location: Chr1:182782353-182804010 bp, + strand Genetic Position: Chr1, 86.12 cM
• Alliance: Tlr5^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112391
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the coding exon. Northern blot failed to detect transcript in mutants. (J:112391)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr5 Mutation: 57 strains or lines available

References

• Original: J:112391 Uematsu S, et al., Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol. 2006 Aug;7(8):868-74
• All: 59 reference(s)