Tnip2^tm1.1Sley
Targeted Allele Detail

Summary

• Symbol: Tnip2^tm1.1Sley
• Name: TNFAIP3 interacting protein 2; targeted mutation 1.1, Steven C Ley
• MGI ID: MGI:3664444
• Synonyms: Tnip2^-, Tnip2^delta
• Gene: Tnip2 Location: Chr5:34653440-34671323 bp, - strand Genetic Position: Chr5, 17.89 cM
• Alliance: Tnip2^tm1.1Sley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112395
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a targeting vector into PC3 ES cells placed a loxP site in intron 2 and a floxed neo resistance cassette in intron 5. Cre-mediated excision removed exons 3-5 upon transmission from male chimeras. Immunoblot confirmed absence of protein in mutant mice. (J:112395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnip2 Mutation: 23 strains or lines available

Notes

PC3 ES cells are homozygous for Tg(Prm-cre)70Og, a transgene that expresses Cre recombinase only in haploid spermatids.

References

• Original: J:112395 Papoutsopoulou S, et al., ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol. 2006 Jun;7(6):606-15
• All: 3 reference(s)