Nr1h3^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Nr1h3^tm1Dgen
• Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1, Deltagen
• MGI ID: MGI:3664445
• Synonyms: Lxra^-
• Gene: Nr1h3 Location: Chr2:91014406-91033179 bp, - strand Genetic Position: Chr2, 50.52 cM
• Alliance: Nr1h3^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A 42 bp fragment of exon 2 was replaced by a PGK-neo cassette. (J:112995)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h3 Mutation: 32 strains or lines available

References

• Original: J:112995 Plosch T, et al., Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2006 Sep;291(3):G414-23
• All: 6 reference(s)