Serpina6^tm1Tew
Targeted Allele Detail

Summary

• Symbol: Serpina6^tm1Tew
• Name: serine (or cysteine) peptidase inhibitor, clade A, member 6; targeted mutation 1, Thomas E Willnow
• MGI ID: MGI:3664470
• Synonyms: cbg^-
• Gene: Serpina6 Location: Chr12:103612889-103623471 bp, - strand Genetic Position: Chr12, 52.98 cM
• Alliance: Serpina6^tm1Tew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112974
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/SvEmcTer

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neo replaced most of exon 2. Absence of protein was confirmed by Western blot analysis. (J:112974)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpina6 Mutation: 34 strains or lines available

Notes

ES cell line = ICp4

References

• Original: J:112974 Petersen HH, et al., Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin. Mol Cell Biol. 2006 Oct;26(19):7236-45
• All: 4 reference(s)