Chst5^tm1Knsh
Targeted Allele Detail

Summary

• Symbol: Chst5^tm1Knsh
• Name: carbohydrate sulfotransferase 5; targeted mutation 1, Kohji Nishida
• MGI ID: MGI:3664471
• Gene: Chst5 Location: Chr8:112615767-112636831 bp, - strand Genetic Position: Chr8, 58.11 cM, cytoband E1
• Alliance: Chst5^tm1Knsh page

Corneas of wild type, Chst5^tm1Knsh/Chst5⁺ and Chst5^tm1Knsh/Chst5^tm1Knsh mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin-resistance gene. RT-PCR confirmed the absence of transcript in the whole eyes of null mice. (J:112899)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chst5 Mutation: 76 strains or lines available

References

• Original: J:112899 Hayashida Y, et al., Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13333-8
• All: 4 reference(s)