Tg(Pcp2-cre)3Mdk
Transgene Detail

Summary

• Symbol: Tg(Pcp2-cre)3Mdk
• Name: transgene insertion 3, Michael D Koob
• MGI ID: MGI:3664534
• Synonyms: P-CRE-3
• Transgene: Tg(Pcp2-cre)3Mdk Location: unknown
• Alliance: Tg(Pcp2-cre)3Mdk page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pcp2-cre)3Mdk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pcp2

• Mutation details: This transgene consists of a 835 bp fragment of the purkinje cell protein 2 5' regulatory region, 1.3 kb of Cre recombinase, and 240 bp of simian virus 40 polyA signal. This transgene expresses cre specifically in Purkinje cells. A transgenic line Tg(Pcp2-cre)1Mdk was also produced but was less effective. (J:112937)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pcp2 (species not specified) Summary of all recombinase alleles driven by Pcp2. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:112937 He Y, et al., Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits. J Neurosci. 2006 Sep 27;26(39):9975-82
• All: 1 reference(s)