Apobec1^tm1Ishi
Targeted Allele Detail

Summary

• Symbol: Apobec1^tm1Ishi
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; targeted mutation 1, Shun Ishibashi
• MGI ID: MGI:3664540
• Gene: Apobec1 Location: Chr6:122554751-122579403 bp, - strand Genetic Position: Chr6, 57.68 cM
• Alliance: Apobec1^tm1Ishi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41982
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 6. Western blot analysis of total protein from jejunum of homozygous mice showed that no detectable protein is expressed from this allele. (J:41982)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apobec1 Mutation: 28 strains or lines available

References

• Original: J:41982 Osuga J, et al., Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1. Biochem Biophys Res Commun. 1997 Jul 18;236(2):375-8
• All: 1 reference(s)