Gli2^tm6Alj
Targeted Allele Detail

Summary

• Symbol: Gli2^tm6Alj
• Name: GLI-Kruppel family member GLI2; targeted mutation 6, Alexandra L Joyner
• MGI ID: MGI:3664541
• Synonyms: Gli2^flox
• Gene: Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
• Alliance: Gli2^tm6Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108507
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted flanking exons 7 and 8, which are upstream of the exons encoding the zinc fingers. A neo cassette flanked with FRT sites was also inserted upstream of exon 7 and then removed with flp DNA recombinase. (J:108507)

Expression

In Mice Carrying this Mutation:	38 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gli2 Mutation: 169 strains or lines available

References

• Original: J:108507 Corrales JD, et al., The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development. 2006 May;133(9):1811-21
• All: 23 reference(s)